EFFECT OF TRANSCRIPTION FACTOR MODULATORS ON OXIDATIVE-NITROSATIVE STRESS INDICATORS IN TISSUES OF THE SMALL INTESTINE OF RATS AFTER LAPARATOMY UNDER LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE

This study is devoted to investigating the effect of NF-κB and Nrf2 transcription factor modulators on oxidative-nitrosative stress indicators in tissues small intestine rats after abdominal surgical trauma (laparotomy) under lipopolysaccharide (LPS)-induced systemic inflammatory response (SIR). The was performed 35 Wister white male weighing 220-250 g, divided into 5 groups: 1st (control) group included "sham-operated" animals; 2nd involved rats, who underwent laparotomy following LPS-induced SIR modelling; animals 3rd, 4th 5th groups subjected then for 7 days received ammonium pyrrolidine dithiocarbamate, an activation inhibitor, a dose 76 mg/kg intraperitoneally, dimethyl fumarate, inducer, 15 10% sulfoxide solution, water-soluble form quercetin 100 that 10 terms quercetin, respectively. measurements were carried out “sham” operation laparotomy. It has been found use case combined effects LPS S. typhi significantly restrains production superoxide anion radical by various sources (microsomes constitutive isoforms NO-synthase, leukocyte NADPH-oxidase), total inducible NO-synthase activity, formation peroxynitrite rats. also demonstrated ability dimethylfumarate, unlike dithiocarbamate improve synthesis nitric oxide experimental conditions.